LAUSR

Key Points Question What is the association between electronic cigarette (e-cigarette) use and depression? Findings In this cross-sectional study of 892 394 participants in the Behavioral Risk Factor Surveillance System from 2016 to 2017, e-cigarette users had higher odds of reporting a history of clinical diagnosis of depression compared with participants who never used e-cigarettes. In addition, increased frequency of e-cigarette use was associated with incrementally higher odds of reporting depression. Meaning These findings highlight the need for longitudinal studies to examine the association between e-cigarette use and depression, which may be bidirectional.