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Comparison of Risk of Recrudescent Fever in Children With Kawasaki Disease Treated With Intravenous Immunoglobulin and Low-Dose vs High-Dose Aspirin

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Key Points Question Is initial treatment with low-dose aspirin, along with intravenous immunoglobulin, for children with Kawasaki disease associated with an increase in recrudescent fever? Findings In this cohort study… Click to show full abstract

Key Points Question Is initial treatment with low-dose aspirin, along with intravenous immunoglobulin, for children with Kawasaki disease associated with an increase in recrudescent fever? Findings In this cohort study of 260 children with Kawasaki disease, initial treatment with low-dose aspirin was not associated with higher odds of fever recrudescence compared with children treated with high-dose aspirin. In addition, no association was identified between low-dose aspirin and coronary artery abnormality or length of stay. Meaning Given the potential benefits and similar outcomes, further investigation into the use of low-dose aspirin in conjunction with intravenous immunoglobulin for the initial treatment of children with Kawasaki disease is warranted.

Keywords: intravenous immunoglobulin; children kawasaki; low dose; kawasaki disease; dose aspirin

Journal Title: JAMA Network Open
Year Published: 2020

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