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Key Points Question Can circulating microRNAs be used as biomarkers to detect esophageal squamous cell carcinoma? Findings In this case-control study of 566 patients with esophageal squamous cell carcinoma and… Click to show full abstract
Key Points Question Can circulating microRNAs be used as biomarkers to detect esophageal squamous cell carcinoma? Findings In this case-control study of 566 patients with esophageal squamous cell carcinoma and 4965 control patients without cancer, serum samples from patients with esophageal squamous cell carcinoma and control patients were used to establish a model to detect esophageal squamous cell carcinoma using 6 microRNAs in a training set. In the validation set, the model distinguished patients with cancer from control patients with high sensitivity and high specificity (0.96 and 0.98, respectively). Meaning The 6-microRNA model is a promising noninvasive screening tool in esophageal squamous cell carcinoma.
Journal Title: JAMA Network Open
Year Published: 2019
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