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Association of Leukocyte Telomere Length With Mortality Among Adult Participants in 3 Longitudinal Studies

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Key Points Question Is leukocyte telomere length associated with the natural life span of contemporary humans? Findings This cohort study included 3259 participants from 3 longitudinal studies, of whom 1525… Click to show full abstract

Key Points Question Is leukocyte telomere length associated with the natural life span of contemporary humans? Findings This cohort study included 3259 participants from 3 longitudinal studies, of whom 1525 died during the follow-up period. Leukocyte telomere length–associated mortality from noncancer causes increased as participants aged, approaching their age at death. Meaning These data suggest that leukocyte telomere length is associated with a life span limit among contemporary humans.

Keywords: longitudinal studies; leukocyte telomere; telomere length; mortality; participants longitudinal

Journal Title: JAMA Network Open
Year Published: 2020

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