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Key Points Question Is combining immunotherapy with other cancer treatments associated with improved overall survival in patients with brain metastases? Findings In this comparative effectiveness study of 3112 adult patients… Click to show full abstract
Key Points Question Is combining immunotherapy with other cancer treatments associated with improved overall survival in patients with brain metastases? Findings In this comparative effectiveness study of 3112 adult patients who received definitive surgery of the primary cancer site, those who received any treatment plus immunotherapy had better overall survival than those who received no immunotherapy. Results varied with other combined therapies; immunotherapy plus radiation therapy was associated with improved overall survival compared with radiation therapy alone, but immunotherapy plus chemotherapy was not associated with improved overall survival compared with chemotherapy alone. Meaning In this study, immunotherapy plus radiotherapy was associated with improved overall survival compared with radiotherapy alone.
Journal Title: JAMA Network Open
Year Published: 2020
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