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Key Points Question To what extent is the association of pre–percutaneous coronary intervention (PCI) fractional flow reserve (FFR) with clinical outcomes explained by the association of pre-PCI FFR with post-PCI… Click to show full abstract
Key Points Question To what extent is the association of pre–percutaneous coronary intervention (PCI) fractional flow reserve (FFR) with clinical outcomes explained by the association of pre-PCI FFR with post-PCI FFR? Findings In this cohort study of 1488 patients, low pre-PCI FFR was significantly associated with target vessel failure but not mediated by post-PCI FFR. Meaning The results of this study suggest that the prognostic information of pre-PCI FFR may not be associated with the results of PCI, represented as post-PCI FFR, indicating that the prognostic information of pre-PCI FFR may mainly reflect the global atherosclerotic burden of the artery, not the extent of the modifiable epicardial stenosis.
Journal Title: JAMA Network Open
Year Published: 2020
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