LAUSR

Key Points Question Is 1000 mg of sodium benzoate daily an effective adjunctive treatment for early psychosis? Findings In this randomized clinical trial of 100 participants with early psychosis, there was no significant improvement in the total Positive and Negative Syndrome Scale (PANSS) score for those who received 1000 mg of sodium benzoate for 12 weeks compared with those who received placebo. There were no end point differences in any subscales of the PANSS, any secondary clinical measures, nor any blood amino acid concentrations between treatment and placebo groups. Meaning In this study, there was no evidence that adjunctive use of 1000 mg of sodium benzoate daily is an effective treatment for individuals with early psychosis.