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Comparison of Trends in Rates of Sexually Transmitted Infections Before vs After Initiation of HIV Preexposure Prophylaxis Among Men Who Have Sex With Men

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Key Points Question Is access to HIV preexposure prophylaxis (PrEP) associated with the trajectory of preexisting trends in sexually transmitted infections (STIs) among high-risk men who have sex with men… Click to show full abstract

Key Points Question Is access to HIV preexposure prophylaxis (PrEP) associated with the trajectory of preexisting trends in sexually transmitted infections (STIs) among high-risk men who have sex with men (MSM)? Findings In a before-after cohort study of high-risk MSM participating in a population-based PrEP implementation project, STI positivity was high while men were taking PrEP with no increasing trend in quarterly STI positivity, compared with similar high positivity before PrEP but an increase of 8% per quarter. Meaning These findings suggest that studies that do not consider preexisting STI trends may overestimate the association of PrEP with STI incidence.

Keywords: hiv preexposure; men sex; sex men; preexposure prophylaxis; sexually transmitted; transmitted infections

Journal Title: JAMA Network Open
Year Published: 2020

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