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Association of Nongenetic Factors With Breast Cancer Risk in Genetically Predisposed Groups of Women in the UK Biobank Cohort

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Key Points Question Is adhering to healthier lifestyle habits associated with a reduced breast cancer risk even among genetically predisposed groups? Findings This cohort study evaluated 2728 women with breast… Click to show full abstract

Key Points Question Is adhering to healthier lifestyle habits associated with a reduced breast cancer risk even among genetically predisposed groups? Findings This cohort study evaluated 2728 women with breast cancer and 88 489 controls and noted lower risks of breast cancer among women who practice a healthy lifestyle. Factors included in this lifestyle were exercise, healthy weight, low alcohol intake, and no oral contraceptive use, as well as avoiding or limiting use of hormonal replacement therapy to less than 5 years, among low, intermediate, and high genetic risk groups. Meaning Following a healthier lifestyle appears to be associated with a decreased level of risk of breast cancer across all strata of genetic risk.

Keywords: predisposed groups; genetically predisposed; breast cancer; cancer risk; cancer

Journal Title: JAMA Network Open
Year Published: 2020

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