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Association of Modifiable Lifestyle Factors With Cortical Amyloid Burden and Cerebral Glucose Metabolism in Older Adults With Mild Cognitive Impairment

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Key Points Question Are modifiable lifestyle factors associated with cortical amyloid burden or cerebral glucose metabolism in older adults with mild cognitive impairment? Findings This cohort study included 118 older… Click to show full abstract

Key Points Question Are modifiable lifestyle factors associated with cortical amyloid burden or cerebral glucose metabolism in older adults with mild cognitive impairment? Findings This cohort study included 118 older adults with mild cognitive impairment and found that total sleep time was associated with cerebral glucose metabolism after adjusting for covariates and false-discovery rate correction. Meaning In this study, the association of sleep duration with brain function was confirmed in older adults with mild cognitive impairment, thereby strengthening the potential of sleep as an evidence-based intervention for preventing cognitive impairment.

Keywords: adults mild; cognitive impairment; impairment; cerebral glucose; older adults; mild cognitive

Journal Title: JAMA Network Open
Year Published: 2020

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