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Key Points Question Which interventions are cost-effective for the prevention and treatment of schizophrenia? Findings In this decision analytical model using a simulated cohort of 200 000 individuals, the following interventions… Click to show full abstract
Key Points Question Which interventions are cost-effective for the prevention and treatment of schizophrenia? Findings In this decision analytical model using a simulated cohort of 200 000 individuals, the following interventions were found to be cost-effective: practice as usual plus cognitive behavioral therapy for individuals at clinical high risk of psychosis; a mix of hospital admission and crisis resolution and home treatment team for individuals with acute psychosis; receipt of amisulpride, risperidone, or olanzapine combined with family intervention for individuals with first-episode psychosis; and receipt of clozapine for individuals with treatment-resistant schizophrenia. Meaning The results of this study suggest that cost savings and/or additional quality-adjusted life years may be gained by replacing current interventions with more cost-effective interventions.
Journal Title: JAMA Network Open
Year Published: 2020
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