LAUSR

Key Points Question What is the best dosing regimen for augmenting exposure therapy for social anxiety disorder with D-cycloserine? Findings In this double-blind, placebo-controlled, randomized clinical trial involving 152 adults with social anxiety disorder, D-cycloserine augmented the treatment effects when administered before or after the exposure sessions. A tailored approach based on exposure success, as defined by low fear at the end of exposure practice, did not facilitate the therapy effects. Meaning D-cycloserine augments exposure therapy for social anxiety disorder, although further optimizing the effects of D-cycloserine augmentation requires research on identifying the targets for tailored approaches.