LAUSR

Key Points Question What are the clinical manifestations of synthetic cannabinoid intoxication, and are they life threatening? Findings This case series of 30 adult patients describes the acute neurologic and cardiopulmonary complications of synthetic cannabinoid intoxication, including severe toxic encephalopathy, acute respiratory failure, and death. Meaning These findings suggest that synthetic cannabinoids are a continued public health threat, with potential for morbidity and mortality from acute intoxication.