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Key Points Question What is the spectrum of clinical findings associated with antenatal Zika virus exposure, and does an association exist between head circumference at birth and neurodevelopmental outcomes among… Click to show full abstract
Key Points Question What is the spectrum of clinical findings associated with antenatal Zika virus exposure, and does an association exist between head circumference at birth and neurodevelopmental outcomes among Zika virus–exposed children with normocephaly? Findings This cohort study of 219 children found that antenatal Zika virus exposure was associated with a wide spectrum of clinical manifestations in normocephalic children beyond those previously described. The head circumference of normocephalic children was associated with neurodevelopmental outcomes. Meaning Recognition of the variety of clinical phenotypes following antenatal Zika virus exposure, including evaluation of head circumference as a continuous variable, may help ensure early intervention, appropriate cross-disciplinary evaluation, and comprehensive therapeutic care.
Journal Title: JAMA Network Open
Year Published: 2020
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