LAUSR

Key Points Question What are the joint associations of actual age and genetically determined age at menarche with risk of all-cause mortality? Findings This cohort study found that that both actual age and genetically determined age at menarche showed similar U-shaped associations with risk of all-cause mortality in a large group of women. The study also found a significant interaction between actual and genetically determined age at menarche with all-cause mortality; women with mismatch of actual age and genetically determined age at menarche had the highest risk of all-cause mortality. Meaning This study suggests that women with a mismatch of actual age and genetically determined age at menarche may have a significantly higher risk of all-cause mortality than women whose actual age and genetically determined age at menarche are matched.