LAUSR

Key Points Question Is there an association between 2-year neurodevelopmental outcomes and use of opioids and/or benzodiazepines for sedation and analgesia in extremely preterm infants? Findings In this cohort study of 936 infants born at gestational ages between 24 weeks, 0 days, and 27 weeks, 6 days, those exposed to both opioids and benzodiazepines for more than 7 days were more likely to have increased in-hospital morbidities, prolonged length of stay, and lower BSID-III cognitive, motor, and language scores at 2 years’ corrected age compared with infants without exposure or those exposed to opioids or benzodiazepines alone. Meaning In this study, the use of opioids and/or benzodiazepines among extremely preterm infants was associated with adverse effects on 2-year neurodevelopmental outcomes.