LAUSR

Key Points Question Which multidrug-resistant organism (MDRO) intervention is best to implement in a set of health care facilities to reduce the spread of MDROs regionwide? Findings In this computational simulation modeling study of 102 facilities in Orange County, California, the use of an agent-based model indicated that, after 3 years, increasing contact precaution effectiveness and implementing decolonization procedures in 42 target facilities would yield countywide relative decreases in the prevalence of methicillin-resistant Staphylococcus aureus of 1% and 24% and countywide relative decreases in the prevalence of carbapenem-resistant Enterobacteriaceae of 2% and 40%, respectively, but varied with effectiveness. Increasing interfacility communication produced no changes in prevalence or transmission. Meaning This study’s findings suggest that modeling can inform the design of real-world regional interventions to control MDROs when intervening in a set of health care facilities.