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Key Points Question Can incorporating Epstein-Barr virus DNA status into analysis of the tumor-node-metastasis framework improve cancer staging quality in nasopharyngeal carcinoma? Findings In this multicenter prognostic study of 2354… Click to show full abstract
Key Points Question Can incorporating Epstein-Barr virus DNA status into analysis of the tumor-node-metastasis framework improve cancer staging quality in nasopharyngeal carcinoma? Findings In this multicenter prognostic study of 2354 patients in China, a recursive partitioning analysis (RPA)–based staging system that divided nonmetastatic nasopharyngeal carcinoma cases into 3 groups with distinctly different prognoses was developed and validated. The RPA stage system outperformed the current TNM staging and 2 reported RPA staging schemes. Meaning These results suggest that an RPA-based staging system can outperform conventional TMN staging groups for predicting survival rates.
Journal Title: JAMA Network Open
Year Published: 2021
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