LAUSR

Key Points Question What are the epidemiologic trends of and prognostic factors for gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in patients in the US? Findings In this cohort study of 43 751 patients with GEP-NETs, most cases occurred in the rectum and small intestine. The age-adjusted incidence rate of GEP-NETs increased significantly from 1975 to 2015, especially for rectal, localized, and grade 1 GEP-NETs; age, sex, marital status and tumor size, grade, stage, and site were significantly associated with overall survival for patients with GEP-NETs. Meaning The incidence and prevalence of GEP-NETs have continued to increase over 40 years; this study suggests that a predictive model based on prognostic factors may accurately quantify the risk of death among patients with GEP-NETs, indicating that the model has satisfactory clinical practicality.