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Key Points Question To what extent does the triglyceride-glucose index, a novel measure of insulin resistance, explain the association between body mass index and end-stage kidney disease risk? Findings In… Click to show full abstract
Key Points Question To what extent does the triglyceride-glucose index, a novel measure of insulin resistance, explain the association between body mass index and end-stage kidney disease risk? Findings In this population-based cohort study of 176 420 Austrian participants, the triglyceride-glucose index was significantly associated with incident end-stage kidney disease risk. Approximately 40% of the association between body mass index and end-stage kidney disease was mediated through the triglyceride-glucose index. Meaning The findings of this study appear to support the hypothesis of insulin resistance being an important intermediate in the association between obesity and end-stage kidney disease.
Journal Title: JAMA Network Open
Year Published: 2021
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