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Key Points Question Are tumor-infiltrating lymphocytes (TILs) an independent prognostic factor for overall survival among patients with primary cutaneous melanoma? Findings This cohort study identified clinical and histopathologic characteristics of… Click to show full abstract
Key Points Question Are tumor-infiltrating lymphocytes (TILs) an independent prognostic factor for overall survival among patients with primary cutaneous melanoma? Findings This cohort study identified clinical and histopathologic characteristics of 14 436 patients with cutaneous melanoma using a natural language processing algorithm to establish a study cohort of 2624 patients with vertical growth phase melanoma and TIL grade. Kaplan-Meier survival analysis and multivariable analysis showed that brisk TILs were significantly associated with improved overall survival (14% advantage at 5 years) compared with the absence of TILs. Meaning This study suggests that brisk TILs represent an independent prognostic factor for the overall survival of patients with primary cutaneous melanoma.
Journal Title: JAMA Network Open
Year Published: 2021
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