LAUSR

Key Points Question What are the clinicopathological characteristics and prognoses of patients with hepatoid adenocarcinoma of the stomach (HAS), and what is an accurate and efficient method of predicting overall survival (OS) among these patients? Findings In this prognostic study of 315 patients with HAS, 3 risk factors (perineural invasion, preoperative carcinoembryonic antigen levels ≥5 ng/mL, and pathological node category 3b) were independently associated with worse OS among patients with HAS. Based on these risk factors, a nomogram to predict postoperative OS among patients with HAS was developed. Meaning This study found that, among patients with HAS, perineural invasion, preoperative carcinoembryonic antigen levels, and pathological node category 3b were independently associated with OS; an individualized nomogram that was developed to predict postoperative OS had good prognostic value and may be useful as a supplement to the current tumor-node-metastasis staging system.