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Association Between Obstructive Sleep Apnea and Brain White Matter Hyperintensities in a Population-Based Cohort in Germany

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Key Points Question Is obstructive sleep apnea (OSA) associated with brain white matter hyperintensities (WMHs)? Findings In this cohort study of 529 participants of the Study of Health in Pomerania-Trend… Click to show full abstract

Key Points Question Is obstructive sleep apnea (OSA) associated with brain white matter hyperintensities (WMHs)? Findings In this cohort study of 529 participants of the Study of Health in Pomerania-Trend baseline, a statistically significant association was found between increased OSA and increased brain WMHs. Meaning The associations found in this study between OSA and brain WMHs may indicate a novel, potentially treatable white matter disease pathomechanism.

Keywords: brain white; brain; obstructive sleep; sleep apnea; white matter

Journal Title: JAMA Network Open
Year Published: 2021

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