LAUSR

Key Points Question Is caffeine intake associated with major cardiometabolic complications during pregnancy (ie, gestational diabetes [GDM], preeclampsia, gestational hypertension)? Findings In this cohort study of 2802 pregnant women, low and moderate caffeinated beverage intake early in second trimester within current guidelines of less than 200 mg per day were associated with a lower risk for GDM, lower glucose levels at GDM screening, and more favorable cardiometabolic profile compared with no consumption. Caffeine was not associated with gestational hypertension or preeclampsia. Meaning The findings of this study may be reassuring for pregnant women with moderate caffeine intake and should be considered in the context of published data on associations with offspring health.