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Association Between the Sulfur Microbial Diet and Risk of Colorectal Cancer

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Key Points Question Is there an association between a dietary pattern that correlates with sulfur-metabolizing bacteria in the gut and colorectal cancer risk? Findings In 3 large prospective cohort studies… Click to show full abstract

Key Points Question Is there an association between a dietary pattern that correlates with sulfur-metabolizing bacteria in the gut and colorectal cancer risk? Findings In 3 large prospective cohort studies of US men and women, greater adherence to a sulfur microbial diet characterized by high intakes of low-calorie beverages and red meats and low intakes of fruits and vegetables was associated with increased risk of colorectal cancer, after controlling for various risk factors. Meaning This study suggests that sulfur-metabolizing bacteria may mediate the association between diet and colorectal cancer risk and could potentially be targeted for risk mitigation.

Keywords: risk; microbial diet; colorectal cancer; association; sulfur microbial

Journal Title: JAMA Network Open
Year Published: 2021

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