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Key Points Question Was implementation of the CMS Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) in October 2015 associated with improvements in sepsis-associated mortality? Findings In this cohort… Click to show full abstract
Key Points Question Was implementation of the CMS Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) in October 2015 associated with improvements in sepsis-associated mortality? Findings In this cohort study of 117 510 adult patients admitted to 114 US hospitals with clinical evidence of suspected sepsis between October 2013 and December 2017, SEP-1 implementation was associated with an immediate increase in lactate testing rates, no change in already-increasing rates of broad-spectrum antibiotic use, and no change in the combined outcome of in-hospital death or discharge to hospice. Meaning These findings suggest SEP-1 was not associated with improved sepsis outcomes and that alternate approaches to preventing sepsis deaths in hospitals are needed.
Journal Title: JAMA Network Open
Year Published: 2021
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