LAUSR

Key Points Question Is statin use during pregnancy associated with adverse perinatal outcomes? Findings In this cohort study of 1 443 657 pregnancies, in which 469 women were dispensed prescription statins during pregnancy, maternal statin exposure during pregnancy was not associated with increased risk of congenital anomalies among offspring but was associated with low birth weight (<2500 g) and preterm birth compared with no exposure. There were no increases in adverse perinatal outcomes among offspring of women who took statins before conception for more than 3 months and with continuous use of statins after pregnancy compared with women who stopped statin use. Meaning This study suggests that, although statin exposure during pregnancy was associated with preterm labor and low birth weight, there was no association between statin use for periconceptual hyperlipidemia and adverse perinatal outcomes.