LAUSR

Key Points Question Are serum folate and vitamin B12 levels associated with cardiovascular disease (CVD) mortality among patients with type 2 diabetes? Findings In this cohort study of 8067 patients with type 2 diabetes, results suggested nonlinear associations of serum folate and vitamin B12 levels with risk of CVD mortality. Both low and high levels of serum vitamin B12 were associated with a higher risk of CVD mortality, whereas low levels of serum folate were associated with a higher risk of CVD mortality. Meaning These findings suggest that maintaining moderate levels of serum folate and vitamin B12 may decrease the risk of CVD death among patients with type 2 diabetes.