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Key Points Question What is the association of daily (D-PrEP) and event-driven preexposure prophylaxis (ED-PrEP) with HIV incidence among HIV-seronegative men who have sex with men in resource-limited real-world settings?… Click to show full abstract
Key Points Question What is the association of daily (D-PrEP) and event-driven preexposure prophylaxis (ED-PrEP) with HIV incidence among HIV-seronegative men who have sex with men in resource-limited real-world settings? Findings In this nonrandomized controlled trial of 1530 participants, HIV incidence was significantly lower among all PrEP users, D-PrEP users, and ED-PrEP users compared with PrEP nonusers. PrEP users reported no serious adverse events; ED-PrEP users consumed 40% fewer tablets than D-PrEP users, and their medication adherence increased over time. Meaning These findings suggest that D-PrEP and ED-PrEP regimens are both associated with lower HIV incidence and a good safety profile among men who have sex with men and who are at high risk of HIV in resource-limited settings.
Journal Title: JAMA Network Open
Year Published: 2022
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