Key Points Question How does an intensive lifestyle intervention affect the association between variability in adiposity indices and cardiovascular outcomes and deaths among adults with type 2 diabetes? Findings In… Click to show full abstract
Key Points Question How does an intensive lifestyle intervention affect the association between variability in adiposity indices and cardiovascular outcomes and deaths among adults with type 2 diabetes? Findings In this cohort study of 3604 adults with type 2 diabetes, a greater variability in body mass index and waist circumference was independently associated with higher risks of cardiovascular events, cardiovascular mortality, and all-cause mortality in the control group. In the intensive lifestyle intervention group, no association was observed between variability in these indices and the outcomes. Meaning These findings suggest that weight fluctuations during weight loss attempts may lead to increased cardiovascular and mortality risk among individuals with type 2 diabetes.
               
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