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Body Weight Variability and Risk of Cardiovascular Outcomes and Death in the Context of Weight Loss Intervention Among Patients With Type 2 Diabetes

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Key Points Question How does an intensive lifestyle intervention affect the association between variability in adiposity indices and cardiovascular outcomes and deaths among adults with type 2 diabetes? Findings In… Click to show full abstract

Key Points Question How does an intensive lifestyle intervention affect the association between variability in adiposity indices and cardiovascular outcomes and deaths among adults with type 2 diabetes? Findings In this cohort study of 3604 adults with type 2 diabetes, a greater variability in body mass index and waist circumference was independently associated with higher risks of cardiovascular events, cardiovascular mortality, and all-cause mortality in the control group. In the intensive lifestyle intervention group, no association was observed between variability in these indices and the outcomes. Meaning These findings suggest that weight fluctuations during weight loss attempts may lead to increased cardiovascular and mortality risk among individuals with type 2 diabetes.

Keywords: variability; type diabetes; intervention; weight loss; cardiovascular outcomes; body

Journal Title: JAMA Network Open
Year Published: 2022

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