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Key Points Question Is a response-adapted strategy based on early tumor response to radiotherapy associated with improved survival with a functional larynx in patients with resectable locally advanced hypopharyngeal carcinoma?… Click to show full abstract
Key Points Question Is a response-adapted strategy based on early tumor response to radiotherapy associated with improved survival with a functional larynx in patients with resectable locally advanced hypopharyngeal carcinoma? Findings In this cohort study of 423 patients with resectable locally advanced hypopharyngeal carcinoma, a response-adapted strategy based on an early tumor response to radiotherapy improved survival with a functional larynx compared with primary surgery and primary radiotherapy strategies. Meaning These findings suggest that a response-adapted strategy based on an early tumor response to radiotherapy could be considered a feasible laryngeal preservation strategy.
Journal Title: JAMA Network Open
Year Published: 2022
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