LAUSR

Key Points Question Can a 110-second video of a transgender protagonist describing their personal history of coping with depression reduce adolescent transphobia and depression-related stigma? Findings In this randomized clinical trial of 1098 adolescents, a significant change in attitudes was found toward transgender youth only in the intervention groups, especially among participants who self-identified as cisgender and/or of heterosexual orientation. As anticipated, a significant reduction in depression-related stigma was also found across all study groups. Meaning Brief social contact–based videos proved efficacious in reducing adolescent transphobia and depression-related stigma.