LAUSR

Key Points Question Is the administration of tranexamic acid associated with mortality and thromboembolic events in patients with traumatic injury? Findings This systematic review and meta-analysis included 31 randomized clinical trials and observational studies with 43 473 patients, among whom tranexamic acid was associated with lower 1-month mortality compared with the control cohort. Data from tranexamic acid studies, especially thromboembolic events, are largely heterogeneous. Meaning These findings suggest that tranexamic acid may decrease mortality in patients with traumatic injury, but the incidence of thromboembolic events remains unclear because trials and populations with traumatic injury are often not comparable and data vary largely.