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Effect of Pulsed Low-Intensity Ultrasonography on Symptom Relief and Tibiofemoral Articular Cartilage Thickness Among Veterans Affairs Enrollees With Knee Osteoarthritis

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Key Points Question Does 48 weeks of pulsed low-intensity ultrasonography (PLIUS) provide therapeutic benefit for patients with idiopathic knee osteoarthritis? Findings In this randomized clinical trial of 132 adults with… Click to show full abstract

Key Points Question Does 48 weeks of pulsed low-intensity ultrasonography (PLIUS) provide therapeutic benefit for patients with idiopathic knee osteoarthritis? Findings In this randomized clinical trial of 132 adults with symptomatic and radiographic idiopathic knee osteoarthritis, no statistically significant difference was found between PLIUS and sham therapies for clinical symptoms or tibiofemoral cartilage thickness, the coprimary outcomes. Meaning PLIUS as applied in this trial was not effective in ameliorating symptoms or slowing cartilage loss associated with idiopathic knee osteoarthritis.

Keywords: intensity ultrasonography; cartilage thickness; cartilage; low intensity; knee osteoarthritis; pulsed low

Journal Title: JAMA Network Open
Year Published: 2022

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