LAUSR

Key Points Question Are the initial cognitive phenotypes associated with risk of behavioral and psychological symptoms of dementia (BPSDs) in patients with Alzheimer disease pathology (ADP), Lewy body–related pathology (LRP), and mixed ADP-LRP? Findings In this cohort study of 2422 participants, executive and visuospatial symptoms were associated with a higher risk for specific BPSDs compared with amnestic symptoms, whereas language phenotype was associated with a lower risk for some BPSDs. The ADP-LRP group had a higher risk for delusions, auditory and visual hallucinations, and rapid eye movement sleep behavior changes than the ADP group but a lower risk for visual hallucinations and rapid eye movement sleep behavior changes than the LRP group. Meaning These findings suggest that initial cognitive phenotype and underlying neuropathology are associated with subsequent risk for specific BPSDs.