LAUSR

Key Points Question Can a novel methodology using collaborative research coordinated online be successfully applied to the development of a guideline for the diagnosis and treatment of a common infectious disease, pyogenic osteomyelitis? Findings This consensus statement and systematic review using a novel WikiGuidelines methodology addresses 7 questions regarding the management of osteomyelitis, resulting in the establishment of 2 clear recommendations (concerning oral antibiotic therapy for pyogenic osteomyelitis and duration of therapy) and 5 clinical reviews that outline a present lack of adequate, hypothesis-confirming data. Meaning These results suggest that this novel, egalitarian methodology enables a clear separation of established care standards based on hypothesis-confirming evidence from practice preferences that are based on lower quality or no evidence.