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Key Points Question What factors are associated with serum levels of anti–SARS-CoV-2 antibodies after COVID-19 vaccination in healthy young and middle-aged persons at 6 months? Findings In this cohort study… Click to show full abstract
Key Points Question What factors are associated with serum levels of anti–SARS-CoV-2 antibodies after COVID-19 vaccination in healthy young and middle-aged persons at 6 months? Findings In this cohort study of 50 individuals, anti–SARS-CoV-2–specific antibody levels at 2, 4, and 6 months after COVID-19 vaccination were inversely correlated with body weight. Young and middle-aged healthy adults weighing less than 55 kg maintained a high antibody level 6 months after the second dose of BNT162b2 vaccination. Meaning In this study, the inverse correlation of anti–SARS-CoV-2–specific antibody levels with weight was sustained up to 6 months after vaccination; further studies are needed to clarify the antibody cutoff level to protect individuals from severe infection.
Journal Title: JAMA Network Open
Year Published: 2022
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