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Comparison of Seroconversion in Children and Adults With Mild COVID-19

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Key Points Question What proportion of children with mild SARS-CoV-2 infection undergo seroconversion compared with adults? Findings In this cohort study of 57 children and 51 adults, the proportion of… Click to show full abstract

Key Points Question What proportion of children with mild SARS-CoV-2 infection undergo seroconversion compared with adults? Findings In this cohort study of 57 children and 51 adults, the proportion of children with seroconversion to SARS-CoV-2 was half that found in adults despite similar viral load. Meaning These findings suggest that serology may provide a less reliable marker of prior SARS-CoV-2 infection in children and support strategies to protect children against COVID-19, including vaccination.

Keywords: adults mild; comparison seroconversion; seroconversion; seroconversion children; sars cov; children adults

Journal Title: JAMA Network Open
Year Published: 2022

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