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Key Points Question Are trimethylamine N-oxide (TMAO), a novel plasma metabolite derived from L-carnitine and phosphatidylcholine, and related metabolites (ie, choline, betaine, carnitine, and butyrobetaine) associated with risk of death… Click to show full abstract
Key Points Question Are trimethylamine N-oxide (TMAO), a novel plasma metabolite derived from L-carnitine and phosphatidylcholine, and related metabolites (ie, choline, betaine, carnitine, and butyrobetaine) associated with risk of death among older adults in the general US population? Findings In this cohort study of 5333 older adults enrolled in the Cardiovascular Heart Study, TMAO and related metabolites were positively associated with risk of death, and this risk was highest among those with lower kidney function. Meaning This study’s findings suggest that circulating TMAO is an important novel risk factor associated with risk of death among older adults.
Journal Title: JAMA Network Open
Year Published: 2022
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