Key Points Question What proportion of individuals living in southern New England had immunity to SARS-CoV-2, either through past infection or vaccination, by May 31, 2021? Findings This case series… Click to show full abstract
Key Points Question What proportion of individuals living in southern New England had immunity to SARS-CoV-2, either through past infection or vaccination, by May 31, 2021? Findings This case series analysis for Rhode Island, Massachusetts, and Connecticut revealed that two-thirds of residents were immune to SARS-CoV-2 by May 31, 2021. The population immune fraction was lower than desired because 27% of vaccines during the winter to spring 2021 vaccination campaign were administered to individuals who were already seropositive. Meaning These findings suggest that SARS-CoV-2 population immunity was overestimated in summer 2021 and that future emergency-setting vaccination campaigns may need to exceed traditional coverage goals.
               
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