LAUSR

Key Points Question Is nighttime masked uncontrolled hypertension (MUCH) in patients with chronic kidney disease (CKD) not receiving dialysis associated with worse cardiovascular and kidney outcomes? Findings In this cohort study of 675 patients with hypertension and nondialysis CKD, approximately one-third of patients had nighttime MUCH, consisting of 13.0% day-night MUCH and 22.8% isolated nighttime MUCH. Day-night MUCH was associated with left ventricular hypertrophy, and isolated nighttime MUCH was associated with kidney function deterioration. Meaning In this study, ambulatory blood pressure monitoring was necessary among patients with CKD to promote the management of nighttime hypertension and to benefit cardiovascular and kidney outcomes, even in patients with controlled office hypertension.