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Association of Dual Decline in Cognition and Gait Speed With Risk of Dementia in Older Adults

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Key Points Question Which cognitive measure among global cognition, memory, processing speed, and verbal fluency is most useful in assessing risk of future dementia when combined with gait decline? Findings… Click to show full abstract

Key Points Question Which cognitive measure among global cognition, memory, processing speed, and verbal fluency is most useful in assessing risk of future dementia when combined with gait decline? Findings In this cohort study of 16 855 relatively healthy older people in Australia and the US, a dual decline in gait and cognitive function compared with nondecliners was significantly associated with increased risk of dementia. This risk was highest in those with both gait and memory decline. Meaning These results highlight the importance of gait in dementia risk assessment and suggest that dual decline in gait speed and a memory measure may be the best combination to assess future dementia.

Keywords: speed; risk; risk dementia; dementia; dual decline

Journal Title: JAMA Network Open
Year Published: 2022

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