Key Points Question Do urine drug test (UDT) results correlate with overdose mortality rates? Findings In this cross-sectional study of 500 000 unique urine specimens collected from substance use disorder… Click to show full abstract
Key Points Question Do urine drug test (UDT) results correlate with overdose mortality rates? Findings In this cross-sectional study of 500 000 unique urine specimens collected from substance use disorder treatment practices, UDT results for 5 drug categories were correlated with overdose mortality rates at national, state, and county levels. Correlation was strongest for synthetic opioids and methamphetamine, and multivariate regression analysis using state-level data revealed that synthetic opioid and methamphetamine UDT positivity rates were significantly associated with overdose deaths. Meaning This study’s findings suggest that UDT is a valuable data source that is capable of informing real-time surveillance efforts.
               
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