LAUSR

Key Points Question What is the association of uric acid–lowering therapy with the development of new onset chronic kidney disease (CKD)? Findings In this cohort study of 269 651 patients with estimated glomerular filtration rate of at least 60 mL/min/1.73 m2 and no albuminuria, there was no beneficial association between initiating uric acid–lowering therapy and the incidence of CKD. Uric acid lowering–therapy was associated with a significantly higher risk of new-onset CKD. Meaning These findings do not support the initiation of uric acid–lowering therapy as a means to prevent the development of CKD.