LAUSR

Key Points Question Is the risk of ventricular tachyarrhythmia similar between women and men with an implantable cardioverter-defibrillator for primary prevention? Findings In this cohort study of 4506 patients with an implantable cardioverter-defibrillator, women and patients with nonischemic cardiomyopathy displayed a significantly lower risk of first and recurrent life-threatening ventricular tachyarrhythmia events than men. In both cardiomyopathy types, risk of ventricular tachyarrhythmia remained significantly higher than risk of death without prior ventricular tachyarrhythmia for women and men, indicating a potential benefit of a primary prevention implantable cardioverter-defibrillator regardless of sex. Meaning Findings suggest that risk of ventricular tachyarrhythmia differs between men and women and by underlying cardiomyopathy, indicating a need for sex-specific risk assessment for primary prevention cardioverter-defibrillator implantation.