LAUSR

Key Points Question What are the diagnostic performances and methodologic challenges of using electronic noses (e-noses) to detect cancer in exhaled breath? Findings This systematic review and meta-analysis identified 52 studies with 3677 patients with cancer, from which pooled analysis found e-noses to have a sensitivity of 90% and a specificity of 87% in detecting cancer. Most studies were feasibility studies with small sample sizes and poor standardization. Meaning Although e-noses were found to have promising accuracy in detecting cancer, there is a need for standardized external validation studies that evaluate their diagnostic accuracy so that their role in the diagnostic workup of cancer can be established.