LAUSR

Key Points Question What is the association between vaccination with the third dose of BNT162b2 vaccine and the incidence of COVID-19 among residents of long-term care facilities? Findings In this cohort study of 18 611 residents at 640 long-term care facilities, the risk of SARS-CoV-2 infection, COVID-19–related hospitalizations, and COVID-19–related deaths was 89% to 96% lower among residents who received the third dose of BNT162b2 vaccine compared with vaccinees who received 2 doses at least 5 months earlier during the Delta variant surge in Israel. Meaning The third dose of BNT162b2 vaccine was associated with a reduced burden of SARS-CoV-2 infection, COVID-19–related hospitalizations, and COVID-19–related deaths in long-term care facilities.