LAUSR

Key Points Question Is prenatal exposure to endocrine-disrupting chemicals (EDCs) associated with liver injury and hepatocellular apoptosis in school-aged children? Findings In the Human Early-Life Exposome population-based cohort study of 1108 mother-child pairs from 6 European countries, prenatal exposures to EDC mixtures, including organochlorine pesticides, polybrominated diphenyl ethers, perfluoroalkyl substances, and metals, significantly increased the risk for liver injury and/or hepatocellular apoptosis in school-aged children. Meaning These findings suggest that exposure to mixtures of EDCs during the sensitive pregnancy period may increase the risk for liver injury and hepatocellular apoptosis in childhood, potentially contributing to the current epidemic of pediatric nonalcoholic fatty liver disease.