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Platform trials are complex innovative designs in which patients are simultaneously randomized to several experimental treatments and to a common comparator group. 1 Moreover, as the study progresses, new treatments… Click to show full abstract
Platform trials are complex innovative designs in which patients are simultaneously randomized to several experimental treatments and to a common comparator group. 1 Moreover, as the study progresses, new treatments can be added dynamically to the ongoing trial, and nonefficacious treatments can be discontinued during planned interim analyses. By comparing several treatments against a shared, common control group and offering an open-ended infrastructure allowing to quickly add and remove treatments to the study, platform trials have the potential to accelerate clinical development and bring efficacious treatments to patients faster. These designs are thus increasingly being used in different therapeutic areas, especially in oncology and, more recently, against COVID-19. 2
Journal Title: JAMA network open
Year Published: 2022
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