LAUSR

Key Points Question What factors are associated with penicillin allergy labeling in the pediatric primary care setting? Findings In this birth cohort study of 334 465 children at 90 primary care pediatric practices, non-Hispanic White ethnicity and race was associated with a penicillin allergy label. Most children carrying penicillin allergy labels were labeled before 2 years of age, and many were labeled after receiving 0 or 1 penicillin prescriptions; allergy labeling varied widely across practices. Meaning These findings raise questions regarding the validity of penicillin allergy labels among pediatric outpatients and highlight the importance of and potential targets for allergy labeling stewardship in this population to help curb unnecessary use of second-line antibiotics.